If you’re searching for the latest in skin rejuvenation, polynucleotide treatment is quickly becoming one of the most talked-about options. It is a cellular repair and regenerative skin product that is designed to correct and heal the skin beyond the surface level to address the underlying causes of aging.
It is a new form of therapy that assists to enhance the elasticity, removes fine lines and gives back the youthful glow without appearing artificial. In this guide, we’ll explore what polynucleotide treatment is, how it works, its benefits, and what you can expect from the procedure.
What Are Polynucleotides?
Polynucleotide treatment uses long chains of nucleotides fragments of DNA (and in some cases RNA) derived from sources like highly purified salmon or trout sperm. These DNA fragments are free of whole cells and allergenic proteins, making them compatible with human skin.
Unlike full-DNA or RNA molecules, these polynucleotides are not functioning as genetic material themselves; instead, they act as biostimulators they kick-start repair in damaged skin, stimulate fibroblasts, and promote new collagen and elastin production.
Historically, fragments like these have been used in wound healing and tissue repair long before their aesthetic use, lending medical credibility to present-day treatments.
How Polynucleotide Treatment Works
When you undergo polynucleotide treatment, ultra-purified DNA fragments are injected into the dermis, where they slowly diffuse and integrate with surrounding tissues. These poly nucleotides trigger proliferation of fibroblasts and increase the production of collagen and elastin that aid in restoring the structural network of the skin.
They are also antioxidants and anti-inflammatory agents that neutralize free radicals and reduce stress on the skin to aid in healing. The fragments are slowly replicated over days to weeks, although the signaling effects persist to induce repair.
During the initial period (first week) you will feel more hydrated or slightly smooth. As collagen remodelling increases over 3-4 weeks, it results in increasingly noticeable firmness, elasticity and fine lines.
Key Benefits & Advantages
Polynucleotide treatment offers deeper skin rejuvenation: it helps improve texture, tone, and elasticity by boosting production of collagen and elastin. Wrinkles, fine lines and crepey or sagging skin soften and fade as they get older.
This is particularly useful at the more sensitive parts of the body, such as under the eyes, the neck, the decollette, where the skin is thinner and more inclined to creasing. Dark circles can be refined, mild under-eye hollows can be minimized, and thin skin can be plumped without the use of heavy fillers by the use of polynucleotides.
It also presents a hope of scars, stretch marks and pigmentation problems. It can minimise acne scars, stretch marks and even out patchy skin colour by encouraging skin healing and preventing inflammation.
Regarding longevity, the effects do not occur immediately as with dermal fillers, but over time, with maintenance procedures, the effects may last a few months (typically 3-6 months) long.
Polynucleotides are preferable to hyaluronic acid fillers, or even the usual skin boosters, when you need regeneration as well as volume. They operate on the cellular level, providing natural firmness and texture benefits as opposed to plumping only.
Treatment Procedure & Protocol
Polynucleotide treatment is conducted via injections using either very fine needles (micro-bolus or linear threading) or a blunt-ended cannula for broader, gentler distribution.
The practitioner examines your skin state, sets objectives, and can use numbing cream to minimize pain before the session.
The average course consists of 2 to 3 sessions with an interval of 2 to 4 weeks. The treatment will take 20-30 minutes and you may experience some mild pinching or pressure during the treatment.
Mild redness, swelling or small blebs are to be expected immediately after and they usually disappear in a day or two.
To treat the wound, do not use makeup within 1224 hours, avoid high heat or lasers within several weeks, keep the skin hydrated, and use mild skin care.
Areas That Can Be Treated
Polynucleotide treatment is very versatile and can be used across many parts of the face and body. Popular facial regions are cheeks, nasal labial folds, jawline, under-eyes, forehead, chin and lips.
Sensitive areas like the neck and décolletage are usually done to combat wrinkles, sagging and sun damages.
Treatment can be provided on the body on loose or crepey skin on arms, knees and abdomen; stretch marks and scars can be treated as well.
Another alternative is the scalp: polynucleotides on the scalp will make hair follicles feel younger and aid in hair growth in the thinning regions.
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Risks, Side Effects & Contraindications
Most side effects of polynucleotide treatment are mild and temporary. You might find redness, swelling, tenderness or minor bruising at the injection site. These are solved in 1-3 days.
Other problems that are less frequent are the presence of small lumps or nodules under the skin, itching, or a temporary skin sensitivity. Extremely rare and more severe complications: allergic reactions (particularly in individuals with fish allergies), infection or vascular occlusion (when a blood vessel is damaged).
You should avoid polynucleotide treatment if you are pregnant or breastfeeding, have active skin infection or inflammation in the treatment area, have an autoimmune disease, or known allergy to ingredients (e.g. fish-derived DNA). Also be careful when taking blood thinners or have bleeding disorders.
In a systematic review of PN in aesthetic medicine (219 patients), the safety was generally good, with primarily mild, short-term side effects.
Final Word
Polynucleotide treatment offers a natural way to restore skin health, improve texture, and target signs of aging from within. It is more than quick fixes because it has regenerative effects. If you’re considering polynucleotide treatment, consult a qualified practitioner to see if it’s right for your skin needs. To get a personalized consultation or to make a consultation appointment, contact our clinic staff now and become the first step to healthier and fresher skin.
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